เดดพูล

Ryan Reynolds

Wade / Deadpool

Morena Baccarin

Vanessa

Ed Skrein

Ajax

T.J. Miller

Weasel

Gina Carano

Angel Dust

Leslie Uggams

Blind Al

Brianna Hildebrand

Negasonic Teenage Warhead

Stefan Kapičić

Colossus (voice)

Karan Soni

Dopinder

Randal Reeder

Buck

Michael Benyaer

Warlord

Style Dayne

Jeremy (Pizza Guy)

Kyle Cassie

Gavin Merchant

Taylor Hickson

Meghan Orlovsky

Ayzee

Teen Girl #1

Naika Toussaint

Teen Girl #2

Isaac C. Singleton, Jr.

Boothe

Justyn Shippelt

Arcade Ticket Taker

Donna Yamamoto

Oncologist

Jed Rees

Recruiter